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4th Neuroepigenetics & Neuroepitranscriptomics Conference

1 - 4 October 2025, St Julian's, Malta


Introduction
Epigenetic mechanisms, including chemical modifications of DNA and histones as well as regulation by non-coding RNAs, are fundamental mechanism regulating gene expression. Various epigenetic mechanisms have pivotal roles in the nervous system and aberrant epigenetic regulation contributes to pathogenesis in many brain disorders. In parallel, epitranscriptomic mechansims cover over 170 different modifications of various RNA. Recent studies have shown diverse role of epitranscriptomic regulation of diverse process in the nervous system, from neurogenesis, learning and memory, to regeneration and cancer. The field is particularly excited by the possibility of clinical translation as shown by the recent profound success in using modified mRNA for COVID 19 vaccine. This meeting will bring together pioneers, experts and junior investigator in studying neuroepigenetics and epitranscriptomics to provide an up-to-date and comprehensive picture of epigenetic and epitranscriptomic mechanisms in neural development, reprogramming and cell identity, plasticity, neuronal function and dysfunction, and discuss future directions of the field. The meeting will offer opportunity and platform for graduate students, postdoctoral fellows, clinical fellows and junior investigator to present their work and interact with leaders in the field and for interdisciplinary collaborations.

Key Sessions
•    Epigenetic mechanisms regulating brain development and stem cells 
•    Transcriptional and translational regulation
•    Neuronal specific splicing
•    Brain developmental disorders, aging and neurodegeneration
•    Single-cell transcriptome, epigenomic, epitranscriptomic, and multi-omics analysis
•    Spatial transcriptomic analysis
•    3D epigenome and chromatin topology 
•    Diverse roles of various RNA modifications in basic neurobiology and clinical translation
•    Brain cancer
Speakers
  • Angel Barco European Neuroscience Institute, Germany
  • Anne Brunet Stanford University, United States
  • Gonçalo Castelo-Branco Karolinska Institutet, Sweden
  • Chuan He University of Chicago, United States
  • Guo-Li Ming University of Pennsylvania, United States
  • Anne Schaefer Icahn School of Medicine, United States
  • Barbara Treutlein ETH Zurich, Switzerland
  • Timothy Brady University of Queensland, Australia
  • Yanxiang Deng University of Pennsylvania, United States
  • André Fischer Georg-August-Universität Göttingen, Germany
  • Johannes Graeff EPFL, Switzerland
  • Junjie Guo Yale School of Medicine, United States
  • Ankur Jain MIT, United States
  • Daniel Lim University of California, San Francisco, United States
  • Ram Madabhushi UT Southwestern Medical Center, United States
  • Kate Meyer Duke University, United States
  • Alexi Nott Imperial College London, United Kingdom
  • Richard Phillips University of Pennsylvania, United States
  • Jelena Radulovic Albert Einstein College of Medicine, United States
  • Ravikiran Raju MIT, United States
  • Yin Shen University of California, San Francisco, United Kingdom
  • Yanhong Shi City of Hope, United States
  • Na Sun MIT, United States
  • Xiao Wang MIT, United States
  • Xiaoqun Wang Institute of Biophysics, China
  • Anne West Duke University, United States

Venue
The Hilton Malta

The Hilton Malta, Vjal Portomaso, St Julian's, PTM 01, Malta

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