Matthew Lockett
University of North Carolina at Chapel Hill
Biography
Matthew obtained his B.S. in Chemistry from the University of Pittsburgh, where he performed undergraduate research in the laboratory of Stéphane Petoud. He received his Ph.D. in Chemistry from the University of Wisconsin at Madison under the supervision of Lloyd M. Smith.
From 2010-2013, he was a postdoctoral fellow at Harvard University, working in the laboratory of George M. Whitesides. Matthew is an Associate Professor at the University of North Carolina at Chapel Hill.
Matthew's laboratory focuses on two distinct research areas, developing new tools and methods to better understand the chemistry occurring in complex environments and interfaces. (1) Bioanalysis techniques focused on probing cellular responses to oxygen and extracellular signaling gradients in 3D tissue- and tumor-like structures. These studies focus on estrogen signaling in healthy and tumorigenic breast models, drug resistance mechanisms in breast and colorectal tumor models, the regulation of drug-metabolizing enzymes along the liver sinusoid, and the altered cellular biochemistry that results from exposure to per- and poly-fluorinated substances (PFAS). (2) Surface analysis of chemically modified photoelectrodes, focusing on carbon- and silicon-based materials. These studies work to elucidate structure-function relationships in materials whose surfaces cannot undergo self-assembly and, thus are intrinsically disordered.
RSC affiliations
Editorial board, Analytical Methods